Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes

Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes

Prostate cancer is the second leading cause of cancer-related death. The androgen deprivation therapy is the standard treatment for advanced stages. Unfortunately, virtually all tumors become resistant to androgen withdrawal. The progression to castration-resistance is not fully understood, although a recent paper has suggested translationally controlled tumor protein to be implicated in the pr...

Translationally Controlled Tumor Protein

Translationally Controlled Tumor-Associated Protein

Translationally-controlled tumor-associated protein (TCTP) has been discovered in 1983 in mouse erythroleukemia cells. Over the years, it became evident that TCTP is an important player in a number of basic cell physiology events in cancer, embryo development, cell cycle, apoptosis, proliferation, growth, stress response, allergy, gene regulation, and heatshock response. However, despite the ne...

Correlation between staining intensity of prostatic adenocarcinoma with P53 and Gleason's grading

Introduction: Prostatic adenocarcinoma is the most common malignancy of internal system and after lung cancer is the second cause of death in male. Genetic base of many neoplasms is related to suppressor tumor gene such as P53. Therefore, we aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with P53 staining method and its relationship with Gleason grade. ...

Translationally controlled tumor protein is a target of tumor reversion.

By analyzing the gene expression profile between tumor cells and revertant counterparts that have a suppressed malignant phenotype, we previously reported a significant down-regulation of translationally controlled tumor protein (TCTP) in the revertants. In the present study, we derived, by using the H1 parvovirus as a selective agent, revertants from three major solid cancers: colon, lung, and...